Hair loss is more than just a cosmetic concern — it’s an emotional struggle that many men and women face every day. Watching your hairline recede or noticing thinning patches in the mirror can be frustrating and disheartening. Whether it’s the genetic hand you’ve been dealt, the hormonal shifts that come with age, or the stress of daily life taking its toll, hair loss can feel like a battle you never signed up for. For many, it’s not just about aesthetics — it’s about confidence, identity, and feeling like yourself again.

The challenge for many, however, isn’t just about finding the right treatment; it’s finding the time to commit to frequent clinic visits. Here at Terra Medical Clinic, our doctors believe that you can take control of your hair regrowth journey without disrupting your daily routine — and the Calecim Advanced Hair System lets you do just that. You can apply the treatment yourself and seamlessly integrate it into your everyday life, all while benefiting from effective scientifically-backed hair restoration.

Developed through stem cell research, this treatment goes beyond surface-level fixes. It works at a cellular level to reactivate dormant hair follicles, strengthen existing strands, and encourage natural hair regrowth. Using a proprietary blend of growth factors, cytokines, and proteins, the system provides the scalp with the nutrients it needs to support thicker, healthier hair growth, without invasive procedures or harsh chemicals. 

First, Let’s Understand Why Your Hair is Thinning

Hair loss doesn’t happen overnight. You may wonder: Why is this happening? Is it stress? Age? Something I’m doing wrong? The truth is, hair loss is complex, and it often stems from a combination of factors; some within your control, others dictated by genetics and biology. Here are the common causes of hair loss: 

Genetic Predisposition

If thinning hair runs in your family, chances are, you might experience it too. Male and female pattern baldness (androgenetic alopecia) is the most common cause of hair loss and is largely influenced by inherited genes. This type of hair loss typically follows a predictable pattern — receding hairlines and bald spots in men, while women often notice a widening part or overall thinning.

Hormonal Changes and Imbalances

Hormones play a major role in hair growth. In men, dihydrotestosterone (DHT), a by-product of testosterone, can shrink hair follicles, leading to gradual thinning and eventual baldness [1]. 

Women, on the other hand, may experience hair loss due to:

• Menopause
• Pregnancy
• polycystic ovary syndrome (PCOS)
• thyroid disorders [2]

The fluctuation of hormones in these conditions can disrupt the hair growth cycle, causing more strands to shed than usual.

Stress and Lifestyle Factors

High stress levels can trigger a condition known as telogen effluvium, where the body prematurely pushes hair into the shedding phase [3]. If you’ve ever gone through a particularly stressful period and noticed excessive hair fall months later, this could be the reason. Poor sleep, crash diets, nutritional deficiencies (especially iron, vitamin D, and biotin), and even certain medications can also impact hair health [4].

Environmental Damage and Scalp Health

Our hair is constantly exposed to pollution, UV rays, and harsh hair treatments. Frequent use of heat styling tools, chemical dyes, and tight hairstyles can weaken the hair shaft, leading to breakage and increased shedding. Additionally, poor scalp health—whether due to dandruff, excess oil, or product buildup—can create an environment where hair struggles to thrive.

The Science Behind Hair Regrowth: How Does The Calecim Advanced Hair System Work?

For years, hair loss treatments have focused on surface-level solutions — thickening shampoos, supplements, and topical serums that claim to restore lost hair. But, these methods often fail to address the deeper issue: the health of hair follicles themselves. The Calecim Advanced Hair System takes a scientific, regenerative approach, leveraging stem cell technology to reactivate dormant follicles, strengthen thinning hair, and create optimal conditions for regrowth [5].

Calecim’s breakthrough comes from its foundation in stem cell research, originally developed for medical applications in wound healing and tissue regeneration. Scientists discovered that certain stem cell-derived proteins and growth factors have powerful regenerative properties, which not only aid in skin repair but also stimulate hair follicles to grow stronger, healthier strands.

At the heart of the Calecim Advanced Hair System is PTT-6®, a proprietary complex derived from the umbilical cord lining of ethically sourced red deer. This bioactive serum contains over 3,000 proteins, growth factors, cytokines, and exosomes — all of which play a crucial role in cellular regeneration and follicle activation [6].

Unlike traditional hair loss treatments that only target symptoms, PTT-6® works at the root level to improve scalp and follicle health. Here’s how it makes a difference:

• Reactivates dormant hair follicles: Many cases of hair thinning occur when follicles enter a prolonged dormant phase and stop producing new hair. PTT-6® delivers key growth factors that help wake up inactive follicles, encouraging them to start producing hair again [7].
• Stimulates new hair growth: The proteins and cytokines in the formula promote angiogenesis—the formation of new blood vessels, which helps ensure that follicles receive the oxygen and nutrients needed for sustained hair growth.
• Reduces inflammation that leads to shedding: Scalp inflammation is a major contributor to hair loss, often caused by factors like stress, environmental pollutants, and hormonal imbalances. PTT-6® contains anti-inflammatory molecules that calm the scalp, creating an ideal environment for hair regrowth.
• Strengthens existing hair: By improving follicle health and boosting collagen production, this advanced formula helps thicken existing hair strands, reducing breakage and giving hair a fuller, healthier appearance.

The Calecim Advanced Hair System isn’t just another topical treatment — it’s a clinic-backed, scientifically formulated solution designed to reset the scalp’s regenerative process. Whether used as a standalone treatment or alongside other hair restoration procedures, its ability to harness the power of stem cell-derived factors sets it apart from conventional hair loss remedies.

Clinical Evidence: Scientific Research Supporting Calecim Advanced Hair System

Hair regrowth treatments often promise results but fail to deliver because they do not target the underlying biological mechanisms responsible for hair thinning and loss. The Calecim Advanced Hair System stands apart due to its foundation in stem cell-derived regenerative science, particularly the use of umbilical cord lining stem cells. Existing research on umbilical cord mesenchymal stem cells (MSCs) and their paracrine effects on hair follicles supports the principles behind this treatment.

One study explored the effects of conditioned medium from human umbilical cord blood-derived MSCs on hair growth. Researchers found that these stem cells enhanced the viability of human dermal papilla cells, the key regulators of hair follicle activity [8]. The treatment resulted in an upregulation of hair induction-related proteins, leading to an earlier onset of the anagen (growth) phase and formation of new hair follicles. These effects were linked to growth factors such as vascular endothelial growth factor (VEGF) and insulin-like growth factor binding protein-1 (IGFBP-1), both crucial for hair follicle regeneration. This suggests that umbilical cord-derived stem cells can actively promote hair regrowth by stimulating follicular activity at a cellular level.

Another relevant study examined the therapeutic potential of umbilical cord-derived MSCs in alopecia areata, a condition where hair loss occurs due to autoimmune responses [9]. Patients who received intravenous administration of these MSCs experienced significant hair regrowth, demonstrating the ability of these stem cells to modulate immune responses and reactivate dormant follicles. The study concluded that umbilical cord MSCs could be a viable option for reversing hair loss disorders, which further reinforces the regenerative potential of stem cell-derived treatments like the Calecim Advanced Hair System.

The mechanism behind these regenerative effects is paracrine signalling, a process where stem cells secrete bioactive factors that enhance cell survival, reduce inflammation, and stimulate follicle regeneration. A review of MSC-derived exosomes highlighted their ability to activate dermal papilla cells, promote angiogenesis (new blood vessel formation), and prolong the anagen phase of hair follicles [10]. These processes mirror the effects observed with Calecim’s PTT-6®, which contains over 3,000 growth factors, cytokines, and proteins to support scalp rejuvenation and follicle health.

Although clinical trials directly evaluating Calecim’s PTT-6® are not yet available, the science behind umbilical cord-derived MSCs strongly supports its mechanism of action. The regenerative properties of stem cell-derived proteins and exosomes provide a scientific basis for how the Calecim Advanced Hair System may improve hair density, reactivate follicles, and reduce inflammation contributing to hair loss.

Take Control of Your Treatment and Integrate it Into Your Schedule 

The Calecim Advanced Hair System offers a comprehensive approach to hair rejuvenation, with simple yet effective at-home applications. After an in-clinic consultation with our doctors to assess your suitability for the treatment, you’ll be given the autonomy to have your treatments from home that seamlessly fit into your schedule. 

At-Home Application with Derma Stamp / Derma Roller

The Calecim Advanced Hair System is designed to offer a convenient and effective hair restoration solution that fits into your lifestyle. While clinic treatments are valuable, not everyone has the time for frequent visits. Understanding this, doctors have found a way to help patients conduct their treatment at home, without the need for multiple in-person sessions. The Calecim Advanced Hair system includes an at-home regimen using a derma stamp/roller device, which will help you maintain consistent treatment without disrupting your routine.

In some cases, depending on your scalp condition, we may suggest a combination approach, integrating Calecim with nutraceuticals or medication to enhance hair growth results.

Once you’re set up, the at-home protocol is simple:

• Scalp Preparation: Wash and condition the hair to ensure a clean scalp.
• Derma Stamp/Roller Use: Utilise the provided derma stamp/roller to create microchannels in the targeted areas of the scalp.
• Serum Application: Apply half a vial of the Calecim Advanced Hair System serum to the treated areas.
• Massage: Gently massage the serum into the scalp for at least four minutes to enhance absorption.
• Post-Application Care: Avoid washing the hair for at least 8 hours, preferably 24 hours, post-application.

Treatment Frequency 

An At-Home Treatment with Continued Guidance from Our Doctors

At Terra Medical Clinic, we go beyond just offering hair restoration treatments; we provide personalised solutions according to your specific hair and scalp needs. 

When you visit Terra Medical Clinic, you are not just getting a product; you are receiving guidance and a customised treatment plan with our doctors, ensuring you get the most out of your treatment. Here’s what you can expect:

• Personalised Hair & Scalp Assessment: We analyse your hair density, scalp condition, and underlying factors contributing to hair loss.
• Customised Treatment Plans: Whether you need in-clinic microneedling sessions, at-home applications, or a combination approach with nutraceuticals, we create a plan that works best for you.
• Medical Expertise You Can Trust: Our team stays up to date with the latest advancements in stem cell-based hair restoration, which helps us ensure that you receive a treatment backed by science.
• Ongoing Support: Hair regrowth is a journey, and we are here every step of the way. From tracking progress to adjusting your regimen, we ensure you see the best possible results.

Summary

When it comes to restoring hair growth, it’s not just about finding an effective solution — it’s about choosing one that fits your lifestyle and allows you to stay consistent with your treatments.

Here at Terra Medical Clinic, undergoing the Calecim Advanced Hair System allows you to take autonomy of your hair regrowth journey, while having ongoing support from our doctors, ensuring optimal results. Instead of merely masking the problem, experience a treatment that works on a cellular level by stimulating dormant follicles, reducing inflammation, and creating the optimal conditions for stronger, healthier hair growth.

Take the first step to restore your hair health. Schedule a consultation today for a detailed scalp analysis and personalised treatment plan.

Reference 

1. Asfour, L., Cranwell, W., & Sinclair, R. (2000). Male androgenetic alopecia. In K. R. Feingold, B. Anawalt, M. R. Blackman, A. Boyce, G. Chrousos, E. Corpas, W. W. de Herder, K. Dhatariya, K. Dungan, J. Hofland, S. Kalra, G. Kaltsas, N. Kapoor, C. Koch, P. Kopp, M. Korbonits, C. S. Kovacs, W. Kuohung, B. Laferrère, … D. P. Wilson (Eds.), Endotext. MDText.com, Inc. http://www.ncbi.nlm.nih.gov/books/NBK278957/ 
2. Hasan, R., Juma, H., Eid, F. A., Alaswad, H. A., Ali, W. M., & Aladraj, F. J. (n.d.). Effects of hormones and endocrine disorders on hair growth. Cureus, 14(12), e32726. https://doi.org/10.7759/cureus.32726 
3.  How stress causes hair loss. (2021, April 12). National Institutes of Health (NIH). https://www.nih.gov/news-events/nih-research-matters/how-stress-causes-hair-loss 
4. Guo, E. L., & Katta, R. (2017). Diet and hair loss: Effects of nutrient deficiency and supplement use. Dermatology Practical & Conceptual, 7(1), 1–10. https://doi.org/10.5826/dpc.0701a01 
5. Advanced hair system. (n.d.). Calecim Professional. Retrieved February 19, 2025, from https://calecimprofessional.com/products/advanced-hair-system 
6. Technology. Calecim Pro. Retrieved February 19, 2025, from https://calecimpro.com/pages/technology 
7. PTT-6TM, A novel topical hair serum with stem cell growth factors significantly increases hair growth in patients with hair loss. (n.d.). Calecim Professional. Retrieved February 19, 2025, from https://calecimprofessional.com/blogs/research-library/clinical-abstract-nikolaus-duschek 
8. Bak, D. H., Choi, M. J., Kim, S. R., Lee, B. C., Kim, J. M., Jeon, E. S., Oh, W., Lim, E. S., Park, B. C., Kim, M. J., Na, J., & Kim, B. J. (2018). Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth. The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 22(5), 555–566. https://doi.org/10.4196/kjpp.2018.22.5.555 
9. Ahn, H., Lee, S. Y., Jung, W. J., & Lee, K.-H. (2021). Alopecia treatment using minimally manipulated human umbilical cord-derived mesenchymal stem cells: Three case reports and review of literature. World Journal of Clinical Cases, 9(15), 3741–3751. https://doi.org/10.12998/wjcc.v9.i15.3741 
10.  Oh, H. A., Kwak, J., Kim, B. J., Jin, H. J., Park, W. S., Choi, S. J., Oh, W., & Um, S. (2020). Migration inhibitory factor in conditioned medium from human umbilical cord blood-derived mesenchymal stromal cells stimulates hair growth. Cells, 9(6), 1344. https://doi.org/10.3390/cells9061344 
11. The best stem cell hair treatment to regrow hair quickly. (n.d.). Calecim Pro. Retrieved February 19, 2025, from https://calecimpro.com/blogs/blog/stem-cell-hair-revitalisation